Elaine C. Davis

  • Selected Research Publications

Selected Research Publications

ELASTIN:

Czirok, A., J. Zach, B.A. Kozel, R.P. Mecham, E.C. Davis, and B.J. Rongish (2006) Elastic fiber macro-assembly is a hierarchical, cell motion-mediated process. J Cell Physiol. 207:97-106.

Kozel, B.A, B.J. Rongish, A. Czirok, J. Zach, C.D. Little, E.C. Davis, R.H. Knutsen, J.E. Wagenseil, M.A. Levy, and R.P. Mecham (2006) Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters. J Cell Physiol. 207:87-96.

Urban, Z., J. Gao, F.M. Pope and E.C. Davis (2005) Autosomal dominant cutis laxa with severe lung disease: Synthesis and matrix deposition of mutant tropoelastin. J. Invest. Dermatol. 124:1193-1199.

Urban, Z., J. Zhang, E.C. Davis, G.K. Maeda, A. Kumar, H. Stalker, J.W. Belmont, C.D. Boyd and M.R. Wallace (2001) Supravalvular aortic stenosis: Genetic and molecular dissection of a complex mutation in the elastin gene. Human Genetics 109:512-520.

Robb, B.W., H. Wachi, T. Schaub, R.P. Mecham and E.C. Davis (1999) Characterization of an in vitro model of elastic fiber assembly. Mol. Biol. Cell 10:3595-3605.

Li, D.Y., B. Brooke, E.C. Davis, R.P. Mecham, L.K. Sorensen, B.B. Boak, E.Eichwald, and M.T. Keating (1998) Elastin is an essential determinant of arterial morphogenesis. Nature 393:276-280.

Davis, E.C. and R.P. Mecham (1998) Intracellular Trafficking of Tropoelastin. Matrix Biology 17:243-252.

FIBULIN-5:

Spencer, J.A., S.L. Hacker, E.C. Davis, R.P. Mecham, R.H. Knutsen, D.Y. Li, R.D. Gerard, J.A. Richardson, E.N. Olson and H. Yanagisawa (2005) Altered vascular remodeling in fibulin-5-deficient mice reveals a role for fibulin-5 in smooth muscle cell proliferation and migration. Proc. Natl. Acad. Sci. USA 102:2946-2951.

Yanagisawa, H., E.C. Davis, B.C. Starcher, T. Ouchi, M. Yanagisawa, J.A. Richardson and E.N. Olson (2002) Fibulin-5 is an elastin-binding protein essential for elastic fiber development in vivo. Nature 415:168-171.

FKBP65:

Patterson, C.E., W.R. Abrams, N.E. Wolter, J. Rosenbloom and E.C. Davis (2005) Developmental regulation and coordinate re-expression of FKBP65 and extracellular matrix proteins with extracellular matrix proteins following lung injury suggests a specialized function for this ER immunophilin. Cell Stress Chaperones. 10:285-295

Patterson, C.E., J. Gao, A.P. Rooney and E.C. Davis (2002) Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. Genomics 79:881-889.

Patterson, C.E., T. Schaub, E.J. Coleman and E.C. Davis (2000) Developmental regulation of FKBP65: An ER-localized extracellular matrix binding-protein. Mol. Biol. Cell 11:3925-3935.

Davis, E.C., T.J. Broekelmann, Y. Ozawa and R.P. Mecham (1998) Identification of tropoelastin as a ligand for the 65-kD FK506-binding protein, FKBP65, in the secretory pathway. J. Cell Biol. 140:295-303.

OTHERS:

Loeys, B.L., J. Chen, E.R. Neptune, D.P. Judge, M. Podowski, T. Holm, J. Meyers, C.C. Leitch, N. Katsanis, N. Sharifi, F.L. Xu, L.A. Myers, P.J. Spevak, D.E. Cameron, J. De Backer, J. Hellemans, Y. Chen, E.C. Davis, C.L. Webb, W. Kress, P. Coucke, D.B. Rifkin, A.M. De Paepe and H.C. Dietz (2005) A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat. Genet. 37:275-281.