Nathalie Lamarche

Department of Anatomy and Cell Biology

Department of Biology

Rosalind and Morris Goodman Cancer Centre (GCC)

Laboratory location

Strathcona Anatomy & Dentistry Building, Room 117

Research interests

Dr Lamarche-Vane studies the signaling pathways mediated by the Rho family of GTPases. The Rho family of GTPases has been shown to play a critical role in many aspects of cell biology, ie cell migration, cell adhesion, cell morphology and cell growth. These cellular events are crucial for the normal development and physiology in humans. For instance, in the adult, migration events are involved in the normal physiology as well as in pathology such as metastasis. In embryogenesis, cell migration is an important feature of the development of the nervous system. Dr Lamarche is interested to investigate the role of the Rho GTPases in cell migration, in particular, in the developing nervous system and in the cellular processes leading to metastasis. Using molecular and cellular approaches, she will identify the extracellular cues that regulate the Rho GTPases, how they regulate the Rho proteins and how the Rho proteins, in turn, regulate the morphological changes induced in neuronal cells. Understanding the molecular mechanisms underlying the Rho proteins in cell migration and cell adhesion will be helpful to identify novel drug targets for tumor therapy and neurodegenerative diseases.

Lab personnel -

Research Personnel, Postdocs and graduate students

Teaching

Back to Basics - 4th year medical students

Membrane and Cell signaling 458B - undergraduate course

Cell and Developmental Biology course 540-690D - graduate course

Experimental and Clinical Oncology 516-635D - graduate course

Cellular and Molecular Biology 516-604D - graduate course